About

I am currently a research assistant in the School of Computing Science and the Centre for Bacterial Cell Biology at Newcastle University, UK, as part of the Interdisciplinary Computing and Complex BioSystems (ICOS) research group. At crossroads between molecular biology and engineering, synthetic biology is a science trying to crack the code of life by building it. I want to understand how DNA governs many facets of biological life forms from microscopic regulations at the cellular level to such macroscopic phenomena as senescence, cancer, intelligence and self-awareness. I want to pursue research on building cellular machineries that can perform “simple” defined tasks. Ultimately, I want to design a framework genome that would serve as a platform for programming microbes or cellular machines.

In fact, building such a synthetic genome is a reality still far into the future. Currently, I am set out for an interim research goal: given a mathematical model of a synthetic genetic circuit, determine the what and how of in vivo measurements in terms of resolving discrepancies between the model and the world. This research calls for other enabling studies such as microfluidics, molecular quantification and directed evolution. I have background both in computing and biochemistry. I have worked on various projects involving robotics, artificial intelligence, process control, neural cell recording, animal behaviour measurement and molecular biology. Some of the species worked on include UNIX posix, Linux ubuntu, MacOS leopard, Windows seven, Rattus norvegicus (rodent), Macaca radiata (macaque), Escherichia coli, Clostridium difficile and Bacillus subtilis.

Research interests

  • Synthetic biology
  • Microfluidics
  • Directed evolution

Principal Investigators

Prof. Anil Wipat Prof. Colin Harwood Dr. Jennifer Hallinan Prof. Jeff Errington

Publications

  • T. Perera, L. Thirumangalakudi, E. Glennon, S. Park, M. Insanally, M. Persky, J. Fonseka, A. Dwork, H. Sackeim, J. Coplan, and A. Fenton, “Role of hippocampal neurogenesis in mnemonic segregation: implications for human mood disorders,” World journal of biological psychiatry, 2013.
    [Bibtex]
    @article{Perera:2013p16243,
    abstract = {Objectives. Although hippocampal neurogenesis has been implicated in mood disorders , the precise role new neurons play in mood regulation is not fully elucidated. Here we examine whether neurogenesis improves mood by facilitating segregation of novel ...},
    author = {Perera, T. and Thirumangalakudi, L. and Glennon, E. and Park, S. and Insanally, M. and Persky, M. and Fonseka, J. and Dwork, A. and Sackeim, H. and Coplan, J. and Fenton, A.},
    citeulike-article-id = {12332768},
    citeulike-linkout-0 = {http://informahealthcare.com/doi/abs/10.3109/15622975.2013.768356},
    journal = {World Journal of Biological Psychiatry},
    local-url = {file://localhost/Users/spark/Dropbox/workspace1/Papers/World\%20Journal\%20of\%20\%E2\%80\%A6\%202013\%20Perera.pdf},
    month = jan,
    posted-at = {2013-05-09 09:51:22},
    priority = {2},
    title = {Role of hippocampal neurogenesis in mnemonic segregation: implications for human mood disorders},
    url = {http://informahealthcare.com/doi/abs/10.3109/15622975.2013.768356},
    year = {2013}
    }
  • J. Hallinan, S. Park, and A. Wipat, “BRIDGING THE GAP BETWEEN DESIGN AND REALITY, a dual evolutionary strategy for the design of synthetic genetic circuits,” in Bioinformatics 2012 – international conference on bioinformatics models, methods and algorithms, 2012.
    [Bibtex]
    @inproceedings{Hallinan:2012p3280,
    abstract = {... Genetic Circuits JS Hallinan, S. Park and A. Wipat School of Computing Science, Newcastle University, NE7 4RU, Newcastle upon Tyne, UK {jennifer.hallinan, sungshic . park , anil.wipat}@newcastle.ac.uk Keywords: Synthetic ...},
    author = {Hallinan, J. and Park, S. and Wipat, A.},
    booktitle = {BIOINFORMATICS 2012 - International Conference on Bioinformatics Models, Methods and Algorithms},
    citeulike-article-id = {12332767},
    citeulike-linkout-0 = {http://www.staff.ncl.ac.uk/j.s.hallinan/pubs/BioinformaticsConf.pdf},
    posted-at = {2013-05-09 09:51:22},
    priority = {2},
    title = {{BRIDGING} {THE} {GAP} {BETWEEN} {DESIGN} {AND} {REALITY}, A Dual Evolutionary Strategy for the Design of Synthetic Genetic Circuits},
    url = {http://www.staff.ncl.ac.uk/j.s.hallinan/pubs/BioinformaticsConf.pdf},
    year = {2012}
    }
  • T. Perera, S. Park, and Y. Nemirovskaya, “Cognitive role of neurogenesis in depression and antidepressant treatment,” The neuroscientist, 2008.
    [Bibtex]
    @article{Perera:2008p3278,
    abstract = {Abstract The discovery of newborn neurons in the adult brain has generated enormous interest over the past decade. Although this process is well documented in the hippocampus and olfactory bulb, the possibility of neuron formation in other brain regions is under ...},
    author = {Perera, T. and Park, S. and Nemirovskaya, Y.},
    citeulike-article-id = {12332769},
    citeulike-linkout-0 = {http://nro.sagepub.com/content/14/4/326.short},
    journal = {The Neuroscientist},
    local-url = {file://localhost/Users/spark/Dropbox/workspace1/Papers/The\%20Neuroscientist\%202008\%20Perera.pdf},
    month = jan,
    posted-at = {2013-05-09 09:51:23},
    priority = {2},
    title = {Cognitive role of neurogenesis in depression and antidepressant treatment},
    url = {http://nro.sagepub.com/content/14/4/326.short},
    year = {2008}
    }
    
  • S. Park, N. Draskovci, A. Fenton, C. Sexton, and T. Perera, “Dentate neurogenesis contributes to association of old memory to new memory with subtle but distinct differences,” in Society of biological psychiatry 2008 proceedings, washington d.c., united states, 2008.
    [Bibtex]
    @inproceedings{SPark08,
    author = {Park, S. and Draskovci, N. and Fenton, A. and Sexton, C. and Perera, T.},
    booktitle = {Society of Biological Psychiatry 2008 Proceedings, Washington D.C., United States},
    citeulike-article-id = {12332770},
    posted-at = {2013-05-09 09:51:23},
    priority = {2},
    title = {Dentate neurogenesis contributes to association of old memory to new memory with subtle but distinct differences},
    year = {2008}
    }
  • S. Park, “An integrated approach to radio resource management,” in Wireless 2002 – the 14th annual international conference on wireless communications, 2002.
    [Bibtex]
    @inproceedings{SPark02,
    author = {Park, Sungshic},
    booktitle = {Wireless 2002 - the 14th annual international conference on wireless communications},
    citeulike-article-id = {12332771},
    posted-at = {2013-05-09 09:51:23},
    priority = {2},
    title = {An integrated approach to radio resource management},
    year = {2002}
    }
  • S. Park and A. Sowmya, “Autonomous robot navigation by active visual motion analysis and understanding,” in Proceedings of iapr workshop on machine vision applications, mva 1998, november 17-19, 1998, chiba, japan, 1998, pp. 38-41.
    [Bibtex]
    @inproceedings{DBLP:conf/mva/ParkS98,
    author = {Park, S. and Sowmya, A.},
    booktitle = {Proceedings of IAPR Workshop on Machine Vision Applications, MVA 1998, November 17-19, 1998, Chiba, Japan},
    citeulike-article-id = {12332772},
    pages = {38--41},
    posted-at = {2013-05-09 09:51:23},
    priority = {2},
    title = {Autonomous Robot Navigation by Active Visual Motion Analysis and Understanding},
    year = {1998}
    }

Personal

no personal life. ;)

Last update: 15 July 2014 by Sunny Park  |  All rights reserved